Epigallocatechin gallate regulates the myeloid-specific transcription factor PU.1 in macrophages.
Our previous research demonstrated that PU.1 regulates expression ALOE LOTION of the genes involved in inflammation in macrophages.Selective knockdown of PU.1 in macrophages ameliorated LPS-induced acute lung injury (ALI) in bone marrow chimera mice.Inhibitors that block the transcriptional activity of PU.1 in macrophages have the potential to miti